Summary
This 2023 review surveys fungi and their bioactive molecules for longevity and healthy aging in model organisms. It includes Agaricus subrufescens (almond mushroom), highlighting polysaccharides and related compounds with antioxidant, immunomodulatory, and metabolic effects that may support healthspan. Most evidence summarized is preclinical (yeast, worms, flies, mice) with heterogeneous extracts and dosing, so findings are not directly translatable to humans yet. Safety is generally favorable in the literature, but quality, species ID, and extract standardization vary widely. Overall: promising mechanisms and early signals for A. subrufescens, but we still need well-designed human trials with standardized preparations and clinically meaningful endpoints.
Excerpt
Age-related loss of function brings age-related disease, and therefore it is of primary importance to search for interventions that can help minimize detrimental symptoms people deal with in old age. Fungi have always been given a great deal of attention and reverence in traditional medical practices for their ability to minimize harmful symptoms of diseases. More recently, the role of fungi in influencing healthspan and lifespan is being directly studied in the lab. To treat animal model…
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